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Sunday brings the initial Wear-Tyne derby since 2024, but which side will celebrate – the Black Cats or the Magpies?
"For most of last season, no one would have predicted the Wearside club earning promotion and challenging with Eddie Howe's Newcastle, never mind being above them in the table," commented football expert Chris Sutton.
"Things are very different now, and the way Sunderland play makes me think they've got a real chance."
Sutton is making scoreline guesses for all 380 Premier League games this campaign, against artificial intelligence, readers and a range of guests.
For week 16, he is challenged by England Gaming star Daniel 'Stingray' Ray.
Ray is vying for victory for the national gaming squad – the Football Association's official esports team – at the football simulation European esports championship finals tournament, which takes place at Twickenham Stadium on Saturday.
Viewers can catch Uefa's YouTube, IG Live and TikTok channels, as well as the official Twitch channel and YouTube and England's Twitch.
What are your thoughts with their predictions? Share your own projections below.
The most commonly selected scoreline picked for each game is featured in the scoreboards at the end of this page.
A correct result (picking a win, draw or defeat) is worth 10 points. An accurate scoreline earns 40 points.
Ray, who also plays Gen City and the Premier League champions as well as England, is competing for the first time at the eEuros finals after successfully navigating the preliminary stage.
Eight players will represent their nations at the finals in a knockout format, vying for a six-figure prize fund and a highly sought-after spot in the FC Pro World Championship Play-Ins, with the Danish representative Anders Vejrgang looking to retain the title he won last year.
"I am feeling really good for it," Ray said. "I have a really good coach with me and practice has been going well.
"It's always an honour to play for your country. Obviously when you are younger, you imagine doing it as an actual footballer, but when you pursue a career in this field and there is an opportunity to represent England, putting the shirt on is something unique.
"I overcame Vejrgang 9-4 in qualifying to get here. I've played against him throughout the year just in practice, and in other tournaments before - but I'd never beaten him in a tournament before.
"In my opinion he is the top competitor in the world so defeating him in a tournament like this just delivers a crazy boost of confidence."
Premier League Weekend Preview
Saturday, 13 December
Chelsea vs Everton
Stamford Bridge, 15:00 GMT
The Blues were outstanding against the Gunners at the end of November, when they secured a point after being reduced to 10 men, and many thought this is it, they could possibly be title contenders.
However, since that game, however, they were overpowered by Leeds, looked uninspired against Bournemouth and this week got beaten by Atalanta in the Champions League.
So head coach Enzo Maresca desperately requires a win here to restore momentum, but it will be a challenge because Everton are such a threatening team.
Two of their stars are playing at the top of their game and they have got a bit of a positive run at the moment.
On form you would likely back Everton, while the most sensible prediction would likely be a draw, but I am not going to be sensible.
Chelsea haven't given me any real reason to back them recently, but I just have a feeling Chelsea will take this one because they are at home and they are due a win.
Sutton's prediction: 2-1
Stingray's prediction: With this being at the Bridge, I am going to back Chelsea. I think they will start off really well and go 2-0 up, then Everton will nick one back but then Chelsea score late. 3-1
AI's prediction: 2-0
Liverpool vs Brighton
Anfield, 15:00 GMT
I'll be at this game and it will be interesting to see what we get from Liverpool.
I am really pleased for Reds boss Arne Slot to get such a important victory at Inter Milan on Tuesday after all the discussion with Mohamed Salah this week.
Slot should not have to put up with that drama. I know Salah has been a icon for the club but at its core Slot just wants to win games and there is nothing personal in his team selection.
Liverpool changed their formation against Inter and went with a midfield diamond and two up top.
Everyone is going to be talking about whether Salah is selected for this game, but the only way he is going to be brought back into the fold is if he makes amends.
Slot's primary concern will be on winning this game, but it is a difficult fixture.
You could argue it is the same for most teams but I find Brighton so hard to predict. I always feel they have got a goal in them, but they are defensively susceptible too.
Liverpool need to get back to winning consistently, but I am not sure how much their energy spent at the San Siro will have affected their stamina.
I've selected a couple of Brighton players in my Fantasy Premier League side, so they will probably lose now - but I do think they can get something at Anfield.
Sutton's prediction: 2-2
Stingray's prediction: This is a game which is going to give Liverpool a bit more of their confidence back. Obviously they had a good win in midweek and they can build more momentum here. 2-1
AI's prediction: 3-1
Sunday, 14 December
Sunderland vs Newcastle
Stadium of Light, 14:00 GMT
The Black Cats have had the benefit of a free week while Newcastle had to work so hard against Bayer Leverkusen on Wednesday, only to be pegged back late on.
With the exception of their brilliant performance against Everton a couple of weeks ago, Newcastle's away form has been inconsistent, especially straight after they've played in the Champions League.
I am expecting that tendency to continue on Sunday, and their tiredness is likely to be a key element in how this game goes because of their rivals' energetic style.
We saw how relentless Regis le Bris's side are. They dominated the Gunners, and it was incredible to watch.
Everyone talks about how Granit Xhaka has been outstanding for the Black Cats, and he has been superb, but Noah Sadiki, who plays in midfield with him, has also been one of the top transfers and warrants praise too.
I am expecting this being the best game|most exciting fixture